Systems_Biology

The genomics revolution in molecular biology has created many new and exciting ways to collect data on the scale of the entire genome. These new technologies have created vast quantities of data that can only be handled, analyzed and interpreted with the help of concepts, algorithms and software tools applied specifically to these biological data sets. This is the domain of bioinformatics.  

But to understand the physiology of a living cell, we must also know how these interactions play out in time and space as the cell moves around, feeds, grows, divides, differentiates and eventually dies. These dynamic properties of the networks that control cellular functions are the domain of mathematical modeling in systems biology.


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Systems Biology Course Offerings

Introduction to the fundamental ideas and methods of systems biology by a series of case studies. Applications of statistical methods and computer simulation.

SYSB 2025: Genome analysis, molecular network architecture, dynamical systems, special topics.

Prerequisites: ISC 1106, 1116 or BIOL 1105, 1106, 1115, 1116 and CHEM 1036, 1046 and MATH 1206. 

Co-requisites: ISC 2105, 2115 for SYSB 2025

SYSB 2026: Molecular regulatory systems, metabolic pathways, data mining, special topics. ISC 2106, 2116 for SYSB 2026. 

Flyer: SYSB 2025 Intro to Systems Biology

Experimental techniques in genomics, transcriptomics, and proteomics. Mathematical, statistical, and computational models and methods to analyze these data. Techniques for integrating data from different experiments. Case studies and specific applications in B1 molecular biology, including cancer and infectious diseases. 

Prerequisites: 2025, 2026 and (ISC 2105, 2106, 2115, 2116 or PHYS 2205, 2206, 2215, 2216 and STAT 3615 and CS 1044). 

SYSB 3035: genomics, transcriptomics.

SYSB 3036: proteomics, interactomics, data integration.

In-depth study of how molecular regulatory networks determine the physiological properties of prokaryotic and eukaryotic cells.   

Prerequisites: 2025, 2026, ISC 2105, 2115, 2106, 2116 or PHYS 2205, 2206, 2215, 2216, STAT 3615, CS 1044.

SYSB 3115: Biochemical reaction networks, nonlinear dynamical systems, parameter estimation, bifurcation theory, switches and oscillators, gene regulatory networks, signaling pathways, metabolic networks, neural networks, applications.

SYSB 3116: Stochastic effects, cell cycle and cancer, spatial effects, motility, development, tissue dynamics, applications.

Training and practical experience in the conduct of systems biology research.   

Prerequisites: 3035, 3036, 3115, 3116. Co: 4135 for 4265, 4036 for 4066.

SYSB 4065: Planning a research project and initial execution.

SYSB 4066: Revising and completing the project and writing up the results.

Training and practical experience in written and oral communication skills and in ethical standards of science.   

Prerequisites: 3036, 3046, 3115, 3116. Co: 4065 for 4135, 4066 for 4136. 

SYSB 4055: Career options in systems biology, proposal writing, ethical issues, the impact of systems biology on national and global issues.

SYSB 4066: Oral and written presentations, management and social issues, current literature and developments in systems biology.